糖尿病肾病患者血清胱抑素C的变化及意义

来源:岁月联盟 作者:陈敏 时间:2017-03-19
Mohamed和Roberto也证实HDACs抑制剂(SAHA,MS-275,丁酸钠)可促进肿瘤细胞产生ROS,用抗氧化剂L-NAC可对抗HDAC抑制剂引起的ROS增高和细胞死亡[21,22]。
        HDACs抑制剂可增加DNA损伤,干扰DSB识别,抑制DNA修复,在众多的临床前研究中显示出放射增敏作用。深入了解HDACs抑制剂的放射增敏机制,发掘高效低毒的HDACs抑制剂,都是值得进一步研究的方向。
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