黄芩素药理学研究新进展

　　8 结语

　　黄芩为常用中药，味苦、性寒，归肺、心、肝、胆、大肠经，具有清热泻火、燥湿解毒的功效。黄芩的有效成分之一——黄酮类化合物黄芩素，具有抗菌、抗病毒、抗炎、抗氧化、抗肿瘤、抗纤维化及心脑血管、神经元保护等药理作用，提示黄芩素具有多层次、多途径、多靶点的药理活性作用，黄芩药源丰富，功效广泛，未见明显毒性作用报道，值得进一步研究开发。

【参考文献】
  　[1] Zeng Z, Qian L, Cao L,et al. Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa[J]. Appl Microbiol Biotechnol., 2008,79(1):119.

　　[2] Cao Y, Dai B, Wang Y, et al. In vitro activity of baicalein against Candida albicans biofilms[J]. Int J Antimicrob Agents.,2008,32(1):73.

　　[3] Huang S, Cao YY, Dai BD, et al. In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole[J]. Biol. Pharm. Bull., 2008, 31(12) ：2234.

　　[4] Evers DL, Chao CF, Wang X,et al. Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action[J].Antiviral Res.,2005 ,68(3):124.

　　[5] Blach-Olszewska Z, Jatczak B, Rak A,et al. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. J Interferon Cytokine Res.,2008, 28(9):571.

　　[6] 吴修华，刘 妮，杨 丽，沈海容.黄芩素体内抗甲型流感病毒作用的研究[J].广州中医药大学学报，2009，26(2)：157.

　　[7] 朱 伟，孙红光，朱迅.黄芩苷元对炎症反应的影响[J].中国药理学通报，2009，25(2):194.

　　[8] Sungjae Yoo, Shanshu Han, Young Shin Park，et al. Lipoxygenase Inhibitors Suppressed Carrageenan-Induced Fos-Expression and Inflammatory Pain Responses in the Rat[J].Mol.Cells, 2009, 27: 417.

　　[9] Kyung Jin Woo,Jun Hee Lim, Seong-Il Suh, et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBP β DNA-binding activity [J]. Immunobiology, 2006, 211:359.

　　[10] Nakajima T,Imanishi M,Yamamoto K,et al. Inhibitory effect of baicalein. a flavonoid in Scutellaria Root on eotamin production by human dermal fibroblasts[J].Planta Med,2001,67(2):132.

　　[11] YANG Xiu-Fen,HE Wei,LU Wen-Hong,et al. Effect of scutellarin on liver function after brain ischemia/reperfusion in rats[J].Acta Pharmacol Sin,2003,24(11)1118.

　　[12] Lu NH,Zhang Y,Gao ZG. Nitrite–glucose–glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: Effects of some flavonoids[J].Toxicology in Vitro,2009,23:627.

　　[13] Yuling Zhao, Hailing Li, Zhonghong Gao,et al. Effect of flavonoids extracted from Scutellaria baicalens on hemin-nitrite-H2O2 induced liver injury[J].Eur J Pharm，2006，536(1～2)：192.

　　[14] Aqarwal S,Achari C,Praveen D, et al. Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidemoid carcinoma cells(A431) by modulating the ERK and PI2K-Akt signaling pathways[J].Exp Dermatol,2009，18(11)：939.

　　[15] Duen-Suey Chou,George Hsiao,Yan-An Lai.et al. Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen spcies via 12-lipoxyenase[J].FreeRadicalBiology & Medicine, 2009,46:1997.

　　[16] Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE2 activation[J].Neurobiology of disease,2010，37(1)：118.

　　[17] Min Li-Weber. New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin[J].Cancer Treatment Reviews,2008,35:57.

　　[18] 沈 雯，陆福明，顾 勇,等.黄芩素对高糖诱导近端肾小管上皮细胞外基质及转化生长因子β1表达的影响[J].中华肾脏病杂志，2003，19(3)：173.

　　[19] 陈 雯，张明昌，彭 云，等.黄芩素对人眼球筋膜囊成纤维细胞增生的影响[J].眼科新进展，2007，27(6)：436.

　　[20] Hu Q, Noor M, Wong YF, et al. In vitro anti-fibrotic activities of herbal compounds and herbs [J].Nephrol Dial Transplant, 2009, 24(10):3033.

　　[21] Shimizu I. Sho-saiko-to:Japanese herbal medicine for protection against hepatic fibrosis and carcinoma[J].J Gastroenterol Hepatol,2000,15,D84.

　　[22] 钱生勇，金燕锋. HQS对大鼠实验性缺血损伤心肌的保护作用[J].甘肃中医学院学报，2007，24(2)：15.

　　[23] Xu Y W , Sun L, Liang H, et al. 12/15-Lipoxygenase inhibitor baicalein suppresses PPARγ expression and nuclear translocation induced by cerebral ischemia/reperfusion[J].Brain Research,2009,10(39):761.

　　[24] Pao-Yun Cheng,Yen-Mei lee,Yuan-Sheng Wu,et al. Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro[J].Biochemical Pharmacology, 2007,73:793.

　　[25] Cho H, Lee HY, Ahn DR, et al. Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesis[J].Mol Pharmacol., 2008, 74(1):70.

　　[26] F.-Q. Li, T. Wang, Z. Pei, B,et al. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons[J].J Neural Transm,2005,112:331.

　　[27] Mu X, He G R, Cheng Y X, et al. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro[J].Pharmacology, Biochemistry and Behavior, 2009,92:642.

　　[28] Zhang S, Ye J, Dong G. Neuroprotective Effect of Baicalein on Hydrogen Peroxide-Mediated Oxidative Stress and Mitochondrial Dysfunction in PC12 Cells[J].J Mol Neurosci，2009，9：3.

　　[29] Cha MH, Kim IC, Lee BH, Yoon Y.Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression[J].Med Food，2006，9:145.

　　[30] Kim MH, Ryu SY, Bae MA, et al, Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis[J].Food Chem Toxicol.,2008, 46 (11):3375.