脂蛋白(a)/总胆汁酸联合检测对急性脑梗死诊断的应用研究
来源：岁月联盟
时间：2015-10-12
【关键词】 脂蛋白（a）；总胆汁酸；急性脑梗死
Application of Combined Detection of LipoprotEin(a)and Total Bile Acid in the Diagnosis of Acute Cerebral Infarction
REN Gengpu, QI Zifang, WANG Kejun, et al.
Department of Clinical Laboratory The Second People’s Hospital of Liaocheng,Linqing 252601, China
【Abstract】 Objective To investigate the application of combined detection of serum lipoprotEIn(a)and total bile acid in patients with acute cerebral infarction to make accurate judgments of the state of an illness and to make differential diagnosis of acute cerebral infarction and other cerebral vascular disease based the obtained data.Methods Fasting hemospasia samples were harvested by the common tube in the morning from three groups in patients with acute cerebral infarction who visiting hospital and hospitalize in our hospital, patients with acute cerebral hemorrhage who visiting hospital and hospitalize in our hospital and healthy physical examinees to determine the levels of serum lipoprotein(a)and total bile acid by Roche Hitachi automatic biochemistry analyzer PPI and imported reagent of Randox company. The obtained data was analyzed by means of SPSS software. The data were expressed as x±s, and measured by t test.
Results Compared with patients with acute cerebral hemorrhage control group and healthy physical examinees control group, the serum lipoprotein(a)and total bile acid levels in acute cerebral infarction group increased significantly. There were significant difference between them(P<0.01 or P<0.05). The serum lipoprotein(a)and total bile acid levels were different among various infarct size groups, large infarct size group>small infarct size group>lacunar infarction group.There were significant difference among three groups(P<0.05 or P<0.01).Conclusion Combined detection of lipoprotein(a)and total bile acid can provide more accurate and quick diagnosis and can increase diagnosis positive rate. It shows that the serum lipoprotein(a)and total bile acid play an important role in the development of acute cerebral infarction, and the serum lipoprotein(a)and total bile acid exhibit a positive correlation with severity of disease and infarct size.
【Key words】 Lipoprotein(a); Total bile acid; Acute cerebral infarction
近年来的研究认为脂蛋白（a）［LP（a）］以及总胆汁酸（total bile acidTBA）在动脉粥样硬化以及急性脑梗死的发生发展中都扮演了非常重要的角色。其中，LP（a）是造成动脉粥样硬化的重要危险因素，也是急性脑梗死的独立危险因子［1］。而总胆汁酸则是通过影响脂类的消化和吸收以及胆固醇的代谢而加速动脉粥样硬化和血栓的形成而导致脑梗死的发生［2］。我们选取我院急性脑梗死患者355例及性别和年龄与患者组相似的健康查体者185例、急性脑出血患者132例对其两项指标进行检测，以期发现血清脂蛋白（a）、总胆汁酸对急性脑梗死患者病情的诊断及预后的意义，报告如下。